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Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis 期刊论文

编号：

6277848581600121BCD8AF54BAF3DA39
作者：

Wang, YanHong(王艳红)#^[1,2]Ge, Bin(葛斌)^[2]Yang, XiaoLai(杨孝来)^[2]Zhai, Jing^[2];Yang, LiNing(杨丽宁)^[3]Wang, XiaoXia^[1];Liu, Xia^[1];Shi, JinCheng^[1];Wu, YongJie(吴勇杰)*^[1]
语种：

英文
期刊：

INTERNATIONAL IMMUNOPHARMACOLOGY ISSN：1567-5769 2011 年 11 卷 10 期 (1620 - 1627) ; OCT
收录：
关键词：

Proanthocyanidins from grape seeds Ulcerative colitis Recurrent Antiinflammatory Tumor necrosis factor-alpha Nuclear factor-kappa B
摘要：

The aim of this study was to elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE) on recurrent ulcerative colitis (UC) in rats. GSPE in doses of 100, 200, and 400 mg/kg were intragastrically administered per day for 7 days after recurrent colitis was twice-induced by TNBS. The levels of GSH, as well as the activity of GSH-Px and SOD in colon tissues were measured by biochemical methods. The expression levels of tumor necrosis factor-alpha (TNF-alpha) and the nuclear translocation levels of nuclear factor-kappa B (NF-kappa B) in the colon tissues were measured by enzyme-linked immunosorbent assay methods. Western blotting analysis was used to determine the protein expression levels of inhibitory kappa B-alpha (tau), inhibitor kappa B kinase (IKK alpha/beta), phosphorylated I kappa B alpha and phosphorylated IKK alpha/beta. GSPE treatment was associated with a remarkable increased the activity of GSH-Px and SOD with GSH levels in TNBS-induced recurrent colitis rats as compared to the model group. GSPE also significantly reduced the expression levels of TNF-alpha, p-IKK alpha/beta, p-I kappa B alpha and the translocation of NF-kappa B in the colon mucosa. GSPE exerted a protective effect on recurrent colitis in rats by modifying the inflammatory response and promoting damaged tissue repair to improve colonic oxidative stress. Moreover, GSPE inhibited the TNBS-induced inflammatory of recurrent colitis though blocking NF-kappa B signaling pathways. (C) 2011 Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Yan-Hong,Ge Bin,Yang Xiao-Lai, et al. Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis [J].INTERNATIONAL IMMUNOPHARMACOLOGY,2011,11(10):1620-1627.
APA：

Wang Yan-Hong,Ge Bin,Yang Xiao-Lai,Zhai Jing,&Wu Yong-Jie.(2011).Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis .INTERNATIONAL IMMUNOPHARMACOLOGY,11(10):1620-1627.
MLA：

Wang Yan-Hong, et al. "Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis" .INTERNATIONAL IMMUNOPHARMACOLOGY 11,10(2011):1620-1627.
入库时间：

12/21/2023 1:10:42 PM
更新时间：

12/21/2023 1:10:42 PM

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